Skip to main content

Feeling blue? Drink some red

Drinking and depression have problematic relationship, so the consensus from recent studies that moderate red wine consumption correlates to lower odds of depression may seem hard to swallow. But it is clear that daily wine drinkers show a J-shaped curve for clinical depression: lower in moderation, higher in excess. Some very good data comes from a long term study called PREDIMED (“Prevención con Dieta Mediterránea” (Prevention with Mediterranean Diet)), which is a randomized, multicenter, controlled, clinical trial conducted in Spain involving more than 5500 subjects. At up to 7 years of follow-up, wine intake within the range of 2-7 drinks per week was significantly associated with lower risk of incident depression.
Resveratrol, wine’s miracle molecule, offers a potential explanation though it is likely the whole story. There is an experimental model of depression in rats, allowing for measurement of depressive symptoms in response to various drug treatments (no model yet for the effects of counseling or group therapy.) A recent study found that rats given resveratrol for one week exhibited a dose-dependent decrease in activities correlated to depression. More significantly, this effect was associated with an increase in hippocampal and frontal cortical brain-derived neurotrophic factor (BDNF), a protein implicated in chronic effects of many antidepressants.
While it is tempting to unite these findings into and conclude that wine drinkers have lower rates of depression because of the resveratrol, there is an obvious in that logic: Only moderate consumption of wine has a clinical correlation, and it is likely that much higher doses of resveratrol are needed to raise BDNF levels in the brain than what you get in a glass of wine. Both studies are true, but unrelated.

There are many other factors to consider, such as the role of alcohol, but it may be that moderate wine drinking is a marker for other lifestyle factors that relate to lower incidence of depression or elevation of BDNF in the brain. Maybe I will have a glass of wine and think about it.

Comments

Popular posts from this blog

Wear red and DRINK red for women’s heart health

This Friday Feb 2nd is the annual “wear red” day in Canada and the U.S. to raise awareness for women’s heart health. Why only a day for the number one threat to women’s health? Women are 5 times more likely to succumb to heart disease than breast cancer, which gets a whole month (October.) Another contradiction is that the advice women hear about prevention of breast cancer is the opposite of what you can do to lower the risk of heart disease: a daily glass of wine. Even one drink a day raises your risk of breast cancer, we are told, ignoring the overriding benefits of wine on heart health. Drink red wine to live longer Here’s why I think women should also “drink red.” For starters, wine helps de-stress and celebrates life. Stress is a factor in heart disease, and if that were the only way wine helped it would be worth considering. But the medical evidence is also strong: a daily glass of red wine helps raise the HDL “good cholesterol” levels, which lowers the risk of cardiovascular p…

How globalization of drinking habits threatens the French paradox

It seems that the more studies we see on the relationship between wine and health, and the larger they are, the more contradictory the results. Headlines summarizing comprehensive international studies declare the French paradox dead, and all alcoholic beverages are equally detrimental. I think there is an overlooked explanation for this: over the past several decades, convergence of drinking patterns around the world has separated wine from its role as a daily part of a meal. Globalization has commoditized our views about drink, toppling it from its role as a culturally specific emblem. Global convergence of drinking There are several recent reports summarizing the trend,[i],[ii],[iii]and it applies for both developed and developing countries. Since the early 1960s, wine’s share of global alcohol consumption has more than halved, declining from 35% to 15%. Beer and spirits have taken up the slack, with beer gaining 42% and spirits adding 43%, both large gains. The bigger story howeve…

Which types of wine are the healthiest?

I am often asked after lecturing on the healthful properties of wine which type is best to drink. Since much of the discussion has to do with the polyphenol antioxidants from the skins and seeds of the grape, red wine is the first criterion since it is fermented with the whole grape rather than the pressed juice. This allows for extraction and concentration of these compounds, familiar ones being resveratrol and tannins. But beyond that, which varietals have the highest concentrations?


According to the Roman philosopher Pliny the Elder, “The best kind of wine is that which is pleasant to him that drinks it” but modern science expects more specifics. (The point of course is that if you have a wine that you enjoy you are more likely to drink regularly and therefore reap the benefits.) But there are several difficulties in singling out certain wines for their healthful properties. Which compounds to measure? Are we talking about heart health or the whole gamut? Is it the varietal of the …