Just when we
thought the bloom was off the rosé for resveratrol, the anti-oxidant polyphenol
from red wine with multiple anti-aging properties, along comes new research
giving life to the debate. But first a bit of background: As I detailed in my
book Age Gets Better with Wine, it is well-documented that wine drinkers live
longer and have lower rates of many diseases of aging. Much or the credit for
this has been given to resveratrol, though there isn’t nearly enough of it in
wine to explain the effects. Nevertheless, I dubbed it the “miracle molecule”
and when it was reported to activate a unique life-extension phenomenon via a
genetic trigger called SIRT, an industry was born, led by Sirtris
Pharmaceuticals, quickly acquired by pharma giant Glaxo. The hope was that
resveratrol science could lead to compounds enabling people to live up to 150
years and with a good quality of life.
But alas, researchers
from other labs could not duplicate the results, and clinical studies disappointed.
After a few short years, Glaxo pulled the plug on the project. But SIRT still
seemed to be a key to lifespan extension even if resveratrol was not a direct
activator of it. But the latest study from the Sirtris/Glaxo scientists suggests
that maybe resveratrol may play a role here after all, at least on individual
cells under laboratory conditions. Whether this applies to clinical use of
resveratrol (or routine use of resveratrol supplements) remains speculative
however.
Which brings
us back to the central question of wine and health. Because the amount of
resveratrol in wine is much lower than levels required to produce effects on
cells in the lab, whatever benefits accrue to wine consumption cannot be
attributed to resveratrol. So for now I will continue to take my medicine in the
liquid and more palatable form.
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