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What causes those wine headaches? Hope for a solution

It seems like every time I give a talk about wine and health there is at least one person in the audience who asks about headaches. They would like to drink wine, they say, but sometimes it gives them a headache. Or another frequent question relates to why they didn’t get headaches drinking wine in Europe but domestic wines do; is it the sulfites? The good news is that scientists are developing a good understanding of what triggers headaches for some people, and it doesn’t seem to be sulfites; all wines contain them. It probably isn’t the alcohol, unless you are prone to migraines or to imbibing too much. The culprit for most people is a class of compounds called biogenic amines, the most familiar of which is histamine. These are not products of the wine itself, but of bacterial contaminants. Fortunately there are fairly quick tests that can be done do measure the levels of biogenic amines, though these aren’t routinely done. But without testing, the inherent variability of amine produ...