Skip to main content

the inflammation age

Over the past couple of decades, the importance of chronic inflammation as a mediator of aging has become clear. All those antioxidants we hear so much about are ultimately targeted at inflammation. One dramatic example is the case of cardiovascular disease, where the process of plaque buildup in arteries is now known to relate more to inflammatory processes than simple buildup of cholesterol sludge. So the role of wine as a potential means of controlling inflammation may provide an explanation for some of its anti-aging properties.
71. There are several "markers" of inflammation in the blood, one of the more useful being c-reactive protein. High levels of this correlate to an inflammatory state and premature aging. Diets high in flavonoids such as quercetin (in red wine) result in lower c-reactive protein levels.
72. Research out just this month demonstrates the potent anti-inflammatory capabilities of resveratrol. Scientists in Scotland gave a group of mice a potent inflammatory trigger, to mimic the effects of septic shock. A second group pre-treated with resveratrol had a much diminished response, by blocking the production of two molecules known to be particularly destructive.
73. A diet study from Chile found that adding wine produced a much greater effect at reducing inflammation than adding vegetables, though the two together was best.

Comments

Popular posts from this blog

Wear red and DRINK red for women’s heart health

This Friday Feb 2nd is the annual “wear red” day in Canada and the U.S. to raise awareness for women’s heart health. Why only a day for the number one threat to women’s health? Women are 5 times more likely to succumb to heart disease than breast cancer, which gets a whole month (October.) Another contradiction is that the advice women hear about prevention of breast cancer is the opposite of what you can do to lower the risk of heart disease: a daily glass of wine. Even one drink a day raises your risk of breast cancer, we are told, ignoring the overriding benefits of wine on heart health. Drink red wine to live longer Here’s why I think women should also “drink red.” For starters, wine helps de-stress and celebrates life. Stress is a factor in heart disease, and if that were the only way wine helped it would be worth considering. But the medical evidence is also strong: a daily glass of red wine helps raise the HDL “good cholesterol” levels, which lowers the risk of cardiovascular p…

Which types of wine are the healthiest?

I am often asked after lecturing on the healthful properties of wine which type is best to drink. Since much of the discussion has to do with the polyphenol antioxidants from the skins and seeds of the grape, red wine is the first criterion since it is fermented with the whole grape rather than the pressed juice. This allows for extraction and concentration of these compounds, familiar ones being resveratrol and tannins. But beyond that, which varietals have the highest concentrations?


According to the Roman philosopher Pliny the Elder, “The best kind of wine is that which is pleasant to him that drinks it” but modern science expects more specifics. (The point of course is that if you have a wine that you enjoy you are more likely to drink regularly and therefore reap the benefits.) But there are several difficulties in singling out certain wines for their healthful properties. Which compounds to measure? Are we talking about heart health or the whole gamut? Is it the varietal of the …

The J-curve is dead. Long live the J-curve!

There is a resurgence of debate about the validity of the J-curve, especially as it relates to alcohol and cancer. A 2014 report determined that “alcohol use was positively associated with overall mortality, alcohol-related cancers, and violent death and injuries, but marginally to CVD/CHD” (cardiovascular disease). In other words, there was little benefit if any in terms of heart disease but a big upside risk for cancer and accidental or violent demise. Gone was the French Paradox! The J curve is dead! Or not. Though that statement may be technically true, I looked at look at the data myself and found something different: a strong confirmation of the J-curve for overall mortality, overall cancer deaths, cardiovascular disease, and all “other causes.” This held for both men and women:
    Used under creative commons license from Ferrari P, Licaj I,Muller DC, et al. Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nu…