That “gut feeling” you sometimes get may be more literal
than you think: research continues to reveal the importance of the bacteria in
our digestive tract, called the “gut microbiome.” This symbiotic population of microbes affects
health and well-being in often unexpected ways. The microbiome sends signals to
the central nervous system, regulates inflammation, even influences
cardiovascular health. Wine’s impact on health appears to depend significantly
on the microbiome, and we are now learning that it may not actually be the
constituents of wine that make it healthy for us; it is the things that the
microbiome transforms them into.
How wine promotes a healthy microbiome
Wine’s relationship with the microbiome is a two-way street:
Recent studies[1] demonstrate how wine consumption influences the
composition of the various bacteria, while other research demonstrates how the
microbiome metabolizes wine into components that boost the immune system.[2]
The idea that wine’s health benefits may not derive directly from what’s in it
is revolutionary, and it is re-jiggering the field of nutrition and aging. For nearly
200 years we have gone by the words of the famous 19th century gastronome
Anthelme Brillat-Savarin, who wrote "Tell me what you eat, and I will tell
you what you are,” but that is turning out to be only half right, at least in
the physiologic sense.
How the microbiome enhances the health effects of wine
Here’s how it works: wine encourages a healthy microbiome,
which returns the favor by enhancing what is called bioavailability, the absorption and transport to the tissue where the
active ingredient or nutrient in a food or drug is to have an effect. Wine’s effects are attributed to its
antioxidant polyphenols, but their poor absorption gives them low
bioavailability. This is one reason why
effects in tissue cultures and lab studies don’t predict what happens in people:
you can’t get the same levels in the target organ as you can in cells in a
Petri dish. But think of a healthy
microbiome as a sort of Amazon Prime for wine: it metabolizes wine polyphenols
into compounds that are taken up and
delivered, rapidly and often in a more potent form.
An elegant example of this was published by researchers from
Washington University School of Medicine, who detailed how this phenomenon helps
wine fight influenza. They showed how flavonoids, a class of immune-boosting
polyphenols present in red wine, are altered by a specific type of bacterium in
the colon into a molecule called DAT. This in turn signals the production of
the immune modulator interferon, which then enhanced the survival of mice
inoculated with the flu virus. Inflammation in the lungs was correspondingly lessened
as well.
Similar examples abound for a variety of diseases. One study
demonstrated wine’s influence on gut bacteria in obese subjects with a
condition called metabolic syndrome.
After a period of regular wine consumption, strains of bacteria known as
“intestinal barrier protectors” proliferated, while those producing markers of
inflammation diminished.[3]
So if “you are what you eat,” in the
updated interpretation of Brillat-Savarin’s maxim, you are equally what you
drink, and with wine all the better for it.
[1] Carolina
Cueva , Irene Gil-Sánchez , Begoña Ayuda-Durán , Susana González-Manzano , Ana
MarÃa González-Paramás , Celestino Santos-Buelga , Begoña Bartolomé and M. Victoria Moreno-Arribas . An
Integrated View of the Effects of Wine Polyphenols and Their Relevant
Metabolites on Gut and Host Health. Molecules. 2017 Jan 6;22(1).
[2] The
microbial metabolite desaminotyrosine protects from influenza through type I
interferon. Steed AL,, Christophi G, Kaiko GE, Sun L, Goodwin VM, Jain U,
Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ,
Stappenbeck TS. Science. 2017 Aug 4;357(6350):498-502.
[3] Red
wine polyphenols modulate fecal microbiota and reduce markers of the metabolic
syndrome in obese patients. Moreno-Indias I, Sánchez-Alcoholado L,
Pérez-MartÃnez P, Andrés-Lacueva C, Cardona F, Tinahones F, Queipo-Ortuño MI.
Food Funct. 2016 Apr;7(4):1775-87.
Comments
Post a Comment